NR1H4 Gene

What is the NR1H4 gene?

NR1H4 encodes nuclear receptor subfamily 1 group h member 4 (fxr), a protein involved in bile acid sensing / gut homeostasis. It belongs to the Metabolic category and is part of the Metabolic Regulation biological cluster. NR1H4 encodes FXR (farnesoid X receptor), a nuclear receptor for bile acids that regulates bile acid synthesis, lipid metabolism, and gut barrier function.

Biological role and pathway

NR1H4 is involved in the bile acid sensing / gut homeostasis pathway, which plays a central role in regulating physiological processes relevant to immune defence, cellular energy, and systemic homeostasis. Genes within the Metabolic Regulation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function in these systems — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Known genetic variants

The following variants (SNPs) in the NR1H4 gene have been studied in relation to metabolic and chronic illness. Each variant represents a single nucleotide position where individuals may carry different alleles.

• rs35724— NR1H4 variant
• rs56163822— NR1H4 variant

Conditions studied in relation to NR1H4

Research into NR1H4 variants has explored associations with the following conditions. These are areas of scientific investigation and do not imply that NR1H4 causes or treats any condition.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include NR1H4 and related genes in the metabolic regulation pathway.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Related genes in the Metabolic Regulation pathway

NR1H4 does not act in isolation. The following genes are functionally related and may be analysed together for a more complete picture of your genetic predispositions.

Frequently asked questions