rs35724

What is the rs35724 variant?

rs35724 is a SNP (single nucleotide polymorphism) in the NR1H4 (Nuclear Receptor Subfamily 1 Group H Member 4 (FXR)) gene. It belongs to the Metabolic category and is part of the Metabolic Regulation biological cluster. NR1H4 encodes FXR (farnesoid X receptor), a nuclear receptor for bile acids that regulates bile acid synthesis, lipid metabolism, and gut barrier function.

Biological role and pathway

This variant sits within the NR1H4 gene, which is involved in the bile acid sensing / gut homeostasis pathway. Genes within the Metabolic Regulation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: NR1H4

rs35724 is one of 2 known variants in the NR1H4 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs35724

Research into NR1H4 variants including rs35724 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include NR1H4 and the rs35724 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the NR1H4 gene

The following variants in NR1H4 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions