NR3C1 Gene

What is the NR3C1 gene?

NR3C1 encodes nuclear receptor subfamily 3 group c member 1 (glucocorticoid receptor), a protein involved in glucocorticoid / HPA axis signaling. It belongs to the Immune Signaling category and is part of the Autonomic Nervous System biological cluster. NR3C1 encodes the glucocorticoid receptor (GR), which mediates the anti-inflammatory and metabolic effects of cortisol.

Biological role and pathway

NR3C1 is involved in the glucocorticoid / HPA axis signaling pathway, which plays a central role in regulating physiological processes relevant to immune defence, cellular energy, and systemic homeostasis. Genes within the Autonomic Nervous System cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function in these systems — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Known genetic variants

The following variants (SNPs) in the NR3C1 gene have been studied in relation to immune signaling and chronic illness. Each variant represents a single nucleotide position where individuals may carry different alleles.

• rs6196— NR3C1 variant
• rs6189— NR3C1 variant
• rs41423247— NR3C1 variant

Conditions studied in relation to NR3C1

Research into NR3C1 variants has explored associations with the following conditions. These are areas of scientific investigation and do not imply that NR3C1 causes or treats any condition.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include NR3C1 and related genes in the autonomic nervous system pathway.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Related genes in the Autonomic Nervous System pathway

NR3C1 does not act in isolation. The following genes are functionally related and may be analysed together for a more complete picture of your genetic predispositions.

Frequently asked questions