rs6196

What is the rs6196 variant?

rs6196 is a SNP (single nucleotide polymorphism) in the NR3C1 (Nuclear Receptor Subfamily 3 Group C Member 1 (Glucocorticoid Receptor)) gene. It belongs to the Immune Signaling category and is part of the Autonomic Nervous System biological cluster. NR3C1 encodes the glucocorticoid receptor (GR), which mediates the anti-inflammatory and metabolic effects of cortisol.

Biological role and pathway

This variant sits within the NR3C1 gene, which is involved in the glucocorticoid / HPA axis signaling pathway. Genes within the Autonomic Nervous System cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: NR3C1

rs6196 is one of 3 known variants in the NR3C1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs6196

Research into NR3C1 variants including rs6196 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include NR3C1 and the rs6196 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the NR3C1 gene

The following variants in NR3C1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions