PDE5A Gene

What is the PDE5A gene?

PDE5A encodes phosphodiesterase 5a, a protein involved in cGMP signaling and vasodilation. It belongs to the Vascular category and is part of the Coagulation & Microcirculation biological cluster. PDE5A encodes phosphodiesterase-5, which degrades cGMP in vascular smooth muscle, counteracting NO-driven vasodilation.

Biological role and pathway

PDE5A is involved in the cGMP signaling and vasodilation pathway, which plays a central role in regulating physiological processes relevant to immune defence, cellular energy, and systemic homeostasis. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function in these systems — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Known genetic variants

The following variants (SNPs) in the PDE5A gene have been studied in relation to vascular and chronic illness. Each variant represents a single nucleotide position where individuals may carry different alleles.

• rs3756619— PDE5A variant

Conditions studied in relation to PDE5A

Research into PDE5A variants has explored associations with the following conditions. These are areas of scientific investigation and do not imply that PDE5A causes or treats any condition.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include PDE5A and related genes in the coagulation & microcirculation pathway.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Related genes in the Coagulation & Microcirculation pathway

PDE5A does not act in isolation. The following genes are functionally related and may be analysed together for a more complete picture of your genetic predispositions.

Frequently asked questions