rs3756619

What is the rs3756619 variant?

rs3756619 is a SNP (single nucleotide polymorphism) in the PDE5A (Phosphodiesterase 5A) gene. It belongs to the Vascular category and is part of the Coagulation & Microcirculation biological cluster. PDE5A encodes phosphodiesterase-5, which degrades cGMP in vascular smooth muscle, counteracting NO-driven vasodilation.

Biological role and pathway

This variant sits within the PDE5A gene, which is involved in the cGMP signaling and vasodilation pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: PDE5A

rs3756619 is one of 1 known variant in the PDE5A gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs3756619

Research into PDE5A variants including rs3756619 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include PDE5A and the rs3756619 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions