PECAM1 Gene

What is the PECAM1 gene?

PECAM1 encodes platelet and endothelial cell adhesion molecule 1, a protein involved in endothelial junction. It belongs to the Cell Adhesion category and is part of the Coagulation & Vascular biological cluster. PECAM-1 (CD31) mediates leukocyte transendothelial migration through homophilic interactions at endothelial cell junctions. It also provides anti-apoptotic and anti-thrombotic signals in endothelial cells.

Biological role and pathway

PECAM1 is involved in the endothelial junction pathway, which plays a central role in regulating physiological processes relevant to immune defence, cellular energy, and systemic homeostasis. Genes within the Coagulation & Vascular cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function in these systems — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Known genetic variants

The following variants (SNPs) in the PECAM1 gene have been studied in relation to cell adhesion and chronic illness. Each variant represents a single nucleotide position where individuals may carry different alleles.

• rs668— PECAM1 variant
• rs12953— PECAM1 variant
• rs1131012— PECAM1 variant

Conditions studied in relation to PECAM1

Research into PECAM1 variants has explored associations with the following conditions. These are areas of scientific investigation and do not imply that PECAM1 causes or treats any condition.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include PECAM1 and related genes in the coagulation & vascular pathway.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Related genes in the Coagulation & Vascular pathway

PECAM1 does not act in isolation. The following genes are functionally related and may be analysed together for a more complete picture of your genetic predispositions.

Frequently asked questions