rs1131012
Variant in the PECAM1 gene (Platelet And Endothelial Cell Adhesion Molecule 1)
rs1131012 is a single nucleotide polymorphism (SNP) in the PECAM1 gene, involved in endothelial junction. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1131012 variant?
rs1131012 is a SNP (single nucleotide polymorphism) in the PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1) gene. It belongs to the Cell Adhesion category and is part of the Coagulation & Vascular biological cluster. PECAM-1 (CD31) mediates leukocyte transendothelial migration through homophilic interactions at endothelial cell junctions. It also provides anti-apoptotic and anti-thrombotic signals in endothelial cells.
Biological role and pathway
This variant sits within the PECAM1 gene, which is involved in the endothelial junction pathway. Genes within the Coagulation & Vascular cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1131012 and Long COVID / ME-CFS research
PECAM-1 is expressed on endothelium, platelets, and monocytes, integrating coagulation and inflammation. Variants in PECAM1 affect leukocyte transendothelial migration and endothelial survival, potentially influencing vascular integrity in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: PECAM1
rs1131012 is one of 3 known variants in the PECAM1 gene. To understand the full biological context of this variant, explore the parent gene page.
View PECAM1 gene page →Conditions studied in relation to rs1131012
Research into PECAM1 variants including rs1131012 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include PECAM1 and the rs1131012 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the PECAM1 gene
The following variants in PECAM1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1131012 variant in the PECAM1 gene?
rs1131012 is a single nucleotide polymorphism (SNP) located in the PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1) gene, which is involved in endothelial junction. PECAM-1 (CD31) mediates leukocyte transendothelial migration through homophilic interactions at endothelial cell junctions. It also provides anti-apoptotic and anti-thrombotic signals in endothelial cells.
How may the rs1131012 variant relate to Long COVID or ME/CFS?
PECAM-1 is expressed on endothelium, platelets, and monocytes, integrating coagulation and inflammation. Variants in PECAM1 affect leukocyte transendothelial migration and endothelial survival, potentially influencing vascular integrity in Long COVID.
Can a consumer DNA test detect the rs1131012 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1131012 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for PECAM1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 28286069
- [2]Arteriosclerosis Thrombosis and Vascular Biology
- [3]Journal of Clinical Investigation