SERPING1 Gene

What is the SERPING1 gene?

SERPING1 encodes serpin family g member 1, a protein involved in contact activation inhibition. It belongs to the Coagulation category and is part of the Coagulation & Vascular biological cluster. C1-inhibitor (SERPING1) inhibits factor XIIa, kallikrein, C1r, and C1s, regulating both contact activation and complement activation. Hereditary angioedema (HAE) is caused by SERPING1 mutations causing bradykinin excess and episodic swelling.

Biological role and pathway

SERPING1 is involved in the contact activation inhibition pathway, which plays a central role in regulating physiological processes relevant to immune defence, cellular energy, and systemic homeostasis. Genes within the Coagulation & Vascular cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function in these systems — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Known genetic variants

The following variants (SNPs) in the SERPING1 gene have been studied in relation to coagulation and chronic illness. Each variant represents a single nucleotide position where individuals may carry different alleles.

• rs4926— SERPING1 variant
• rs2511989— SERPING1 variant
• rs11575930— SERPING1 variant

Conditions studied in relation to SERPING1

Research into SERPING1 variants has explored associations with the following conditions. These are areas of scientific investigation and do not imply that SERPING1 causes or treats any condition.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SERPING1 and related genes in the coagulation & vascular pathway.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Related genes in the Coagulation & Vascular pathway

SERPING1 does not act in isolation. The following genes are functionally related and may be analysed together for a more complete picture of your genetic predispositions.

Frequently asked questions