rs11575930
Variant in the SERPING1 gene (Serpin Family G Member 1)
rs11575930 is a single nucleotide polymorphism (SNP) in the SERPING1 gene, involved in contact activation inhibition. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs11575930 variant?
rs11575930 is a SNP (single nucleotide polymorphism) in the SERPING1 (Serpin Family G Member 1) gene. It belongs to the Coagulation category and is part of the Coagulation & Vascular biological cluster. C1-inhibitor (SERPING1) inhibits factor XIIa, kallikrein, C1r, and C1s, regulating both contact activation and complement activation. Hereditary angioedema (HAE) is caused by SERPING1 mutations causing bradykinin excess and episodic swelling.
Biological role and pathway
This variant sits within the SERPING1 gene, which is involved in the contact activation inhibition pathway. Genes within the Coagulation & Vascular cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs11575930 and Long COVID / ME-CFS research
SERPING1 deficiency (hereditary angioedema) is relevant because COVID-19 can trigger HAE attacks and the bradykinin excess model of COVID-19 pathogenesis mirrors HAE physiology. SERPING1 variants may predispose to HAE-like bradykinin storms in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: SERPING1
rs11575930 is one of 3 known variants in the SERPING1 gene. To understand the full biological context of this variant, explore the parent gene page.
View SERPING1 gene page →Conditions studied in relation to rs11575930
Research into SERPING1 variants including rs11575930 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SERPING1 and the rs11575930 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the SERPING1 gene
The following variants in SERPING1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs11575930 variant in the SERPING1 gene?
rs11575930 is a single nucleotide polymorphism (SNP) located in the SERPING1 (Serpin Family G Member 1) gene, which is involved in contact activation inhibition. C1-inhibitor (SERPING1) inhibits factor XIIa, kallikrein, C1r, and C1s, regulating both contact activation and complement activation. Hereditary angioedema (HAE) is caused by SERPING1 mutations causing bradykinin excess and episodic swelling.
How may the rs11575930 variant relate to Long COVID or ME/CFS?
SERPING1 deficiency (hereditary angioedema) is relevant because COVID-19 can trigger HAE attacks and the bradykinin excess model of COVID-19 pathogenesis mirrors HAE physiology. SERPING1 variants may predispose to HAE-like bradykinin storms in Long COVID.
Can a consumer DNA test detect the rs11575930 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs11575930 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for SERPING1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32855509
- [2]New England Journal of Medicine
- [3]Journal of Allergy and Clinical Immunology