TMPRSS2 Gene

What is the TMPRSS2 gene?

TMPRSS2 encodes transmembrane serine protease 2, a protein involved in viral entry proteolysis. It belongs to the Viral Entry category and is part of the Viral Entry & Receptors biological cluster. TMPRSS2 encodes a serine protease that primes SARS-CoV-2 spike protein, facilitating viral entry into host cells.

Biological role and pathway

TMPRSS2 is involved in the viral entry proteolysis pathway, which plays a central role in regulating physiological processes relevant to immune defence, cellular energy, and systemic homeostasis. Genes within the Viral Entry & Receptors cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function in these systems — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Known genetic variants

The following variants (SNPs) in the TMPRSS2 gene have been studied in relation to viral entry and chronic illness. Each variant represents a single nucleotide position where individuals may carry different alleles.

• rs12329760— TMPRSS2 variant
• rs2070788— TMPRSS2 variant

Conditions studied in relation to TMPRSS2

Research into TMPRSS2 variants has explored associations with the following conditions. These are areas of scientific investigation and do not imply that TMPRSS2 causes or treats any condition.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TMPRSS2 and related genes in the viral entry & receptors pathway.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Related genes in the Viral Entry & Receptors pathway

TMPRSS2 does not act in isolation. The following genes are functionally related and may be analysed together for a more complete picture of your genetic predispositions.

Frequently asked questions

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