rs2070788

What is the rs2070788 variant?

rs2070788 is a SNP (single nucleotide polymorphism) in the TMPRSS2 (Transmembrane Serine Protease 2) gene. It belongs to the Viral Entry category and is part of the Viral Entry & Receptors biological cluster. TMPRSS2 encodes a serine protease that primes SARS-CoV-2 spike protein, facilitating viral entry into host cells.

Biological role and pathway

This variant sits within the TMPRSS2 gene, which is involved in the viral entry proteolysis pathway. Genes within the Viral Entry & Receptors cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: TMPRSS2

rs2070788 is one of 2 known variants in the TMPRSS2 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs2070788

Research into TMPRSS2 variants including rs2070788 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TMPRSS2 and the rs2070788 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the TMPRSS2 gene

The following variants in TMPRSS2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions

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