rs1889816

What is the rs1889816 variant?

rs1889816 is a SNP (single nucleotide polymorphism) in the ACO2 (Aconitase 2 (Mitochondrial)) gene. It belongs to the Metabolic category and is part of the Mitochondrial Energy Production & PEM biological cluster. ACO2 encodes mitochondrial aconitase, which catalyzes the conversion of citrate to isocitrate in the TCA cycle.

Biological role and pathway

This variant sits within the ACO2 gene, which is involved in the TCA cycle pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: ACO2

rs1889816 is one of 1 known variant in the ACO2 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs1889816

Research into ACO2 variants including rs1889816 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ACO2 and the rs1889816 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions