rs28931581
Variant in the ADAMTS13 gene (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 13)
rs28931581 is a single nucleotide polymorphism (SNP) in the ADAMTS13 gene, involved in VWF cleavage / TTP prevention. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs28931581 variant?
rs28931581 is a SNP (single nucleotide polymorphism) in the ADAMTS13 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 13) gene. It belongs to the Coagulation category and is part of the Coagulation & Microcirculation biological cluster. ADAMTS13 encodes the protease that cleaves large VWF multimers, preventing thrombotic microangiopathy (TTP).
Biological role and pathway
This variant sits within the ADAMTS13 gene, which is involved in the VWF cleavage / TTP prevention pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs28931581 and Long COVID / ME-CFS research
ADAMTS13 deficiency leads to TTP-like microangiopathy; reduced ADAMTS13 in severe COVID-19 may contribute to microvascular thrombosis relevant to Long COVID organ dysfunction.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: ADAMTS13
rs28931581 is one of 3 known variants in the ADAMTS13 gene. To understand the full biological context of this variant, explore the parent gene page.
View ADAMTS13 gene page →Conditions studied in relation to rs28931581
Research into ADAMTS13 variants including rs28931581 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ADAMTS13 and the rs28931581 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the ADAMTS13 gene
The following variants in ADAMTS13 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs28931581 variant in the ADAMTS13 gene?
rs28931581 is a single nucleotide polymorphism (SNP) located in the ADAMTS13 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 13) gene, which is involved in VWF cleavage / TTP prevention. ADAMTS13 encodes the protease that cleaves large VWF multimers, preventing thrombotic microangiopathy (TTP).
How may the rs28931581 variant relate to Long COVID or ME/CFS?
ADAMTS13 deficiency leads to TTP-like microangiopathy; reduced ADAMTS13 in severe COVID-19 may contribute to microvascular thrombosis relevant to Long COVID organ dysfunction.
Can a consumer DNA test detect the rs28931581 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs28931581 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for ADAMTS13 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32966261
- [2]Nature Genetics
- [3]Blood