rs1127317
Variant in the ADAR gene (Adenosine Deaminase Double-Stranded RNA Specific)
rs1127317 is a single nucleotide polymorphism (SNP) in the ADAR gene, involved in RNA editing / innate immune modulation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1127317 variant?
rs1127317 is a SNP (single nucleotide polymorphism) in the ADAR (Adenosine Deaminase Double-Stranded RNA Specific) gene. It belongs to the Antiviral category and is part of the Viral Defense & Interferon Response biological cluster. ADAR encodes an RNA editing enzyme that converts adenosine to inosine in double-stranded RNA, modulating innate immune sensing.
Biological role and pathway
This variant sits within the ADAR gene, which is involved in the RNA editing / innate immune modulation pathway. Genes within the Viral Defense & Interferon Response cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1127317 and Long COVID / ME-CFS research
ADAR-mediated RNA editing prevents excessive immune activation from endogenous dsRNA; variants may affect innate immune activation and contribute to autoimmune features of Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: ADAR
rs1127317 is one of 1 known variant in the ADAR gene. To understand the full biological context of this variant, explore the parent gene page.
View ADAR gene page →Conditions studied in relation to rs1127317
Research into ADAR variants including rs1127317 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ADAR and the rs1127317 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs1127317 variant in the ADAR gene?
rs1127317 is a single nucleotide polymorphism (SNP) located in the ADAR (Adenosine Deaminase Double-Stranded RNA Specific) gene, which is involved in RNA editing / innate immune modulation. ADAR encodes an RNA editing enzyme that converts adenosine to inosine in double-stranded RNA, modulating innate immune sensing.
How may the rs1127317 variant relate to Long COVID or ME/CFS?
ADAR-mediated RNA editing prevents excessive immune activation from endogenous dsRNA; variants may affect innate immune activation and contribute to autoimmune features of Long COVID.
Can a consumer DNA test detect the rs1127317 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1127317 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for ADAR and its variants. This is not an exhaustive literature review.
- [1]PMID: 32217835
- [2]Nature Genetics
- [3]Science