rs1501299
Variant in the ADIPOQ gene (Adiponectin)
rs1501299 is a single nucleotide polymorphism (SNP) in the ADIPOQ gene, involved in adipokine / anti-inflammatory signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1501299 variant?
rs1501299 is a SNP (single nucleotide polymorphism) in the ADIPOQ (Adiponectin) gene. It belongs to the Neuroendocrine category and is part of the Metabolic Regulation biological cluster. ADIPOQ encodes adiponectin, an anti-inflammatory adipokine with insulin-sensitizing and cardioprotective properties.
Biological role and pathway
This variant sits within the ADIPOQ gene, which is involved in the adipokine / anti-inflammatory signaling pathway. Genes within the Metabolic Regulation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1501299 and Long COVID / ME-CFS research
Adiponectin is generally reduced in obesity and inflammation; low adiponectin may exacerbate Long COVID inflammatory state, with ADIPOQ variants affecting baseline levels.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: ADIPOQ
rs1501299 is one of 3 known variants in the ADIPOQ gene. To understand the full biological context of this variant, explore the parent gene page.
View ADIPOQ gene page →Conditions studied in relation to rs1501299
Research into ADIPOQ variants including rs1501299 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ADIPOQ and the rs1501299 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the ADIPOQ gene
The following variants in ADIPOQ are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1501299 variant in the ADIPOQ gene?
rs1501299 is a single nucleotide polymorphism (SNP) located in the ADIPOQ (Adiponectin) gene, which is involved in adipokine / anti-inflammatory signaling. ADIPOQ encodes adiponectin, an anti-inflammatory adipokine with insulin-sensitizing and cardioprotective properties.
How may the rs1501299 variant relate to Long COVID or ME/CFS?
Adiponectin is generally reduced in obesity and inflammation; low adiponectin may exacerbate Long COVID inflammatory state, with ADIPOQ variants affecting baseline levels.
Can a consumer DNA test detect the rs1501299 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1501299 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for ADIPOQ and its variants. This is not an exhaustive literature review.
- [1]PMID: 33153018
- [2]Nature Genetics
- [3]Diabetes Care