rs2254987
Variant in the AICDA gene (Activation Induced Cytidine Deaminase)
rs2254987 is a single nucleotide polymorphism (SNP) in the AICDA gene, involved in antibody diversification. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2254987 variant?
rs2254987 is a SNP (single nucleotide polymorphism) in the AICDA (Activation Induced Cytidine Deaminase) gene. It belongs to the Adaptive Immunity category and is part of the Adaptive Immunity biological cluster. AID (AICDA) catalyzes cytosine deamination in immunoglobulin gene variable regions to initiate somatic hypermutation and class switch recombination, diversifying antibody responses and enabling isotype switching.
Biological role and pathway
This variant sits within the AICDA gene, which is involved in the antibody diversification pathway. Genes within the Adaptive Immunity cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2254987 and Long COVID / ME-CFS research
Aberrant AID activity can drive off-target mutations leading to autoantibody production and B cell lymphoma. In the hyperactivated B cell responses of COVID-19, elevated AID may contribute to the autoantibody repertoire seen in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: AICDA
rs2254987 is one of 2 known variants in the AICDA gene. To understand the full biological context of this variant, explore the parent gene page.
View AICDA gene page →Conditions studied in relation to rs2254987
Research into AICDA variants including rs2254987 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include AICDA and the rs2254987 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the AICDA gene
The following variants in AICDA are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2254987 variant in the AICDA gene?
rs2254987 is a single nucleotide polymorphism (SNP) located in the AICDA (Activation Induced Cytidine Deaminase) gene, which is involved in antibody diversification. AID (AICDA) catalyzes cytosine deamination in immunoglobulin gene variable regions to initiate somatic hypermutation and class switch recombination, diversifying antibody responses and enabling isotype switching.
How may the rs2254987 variant relate to Long COVID or ME/CFS?
Aberrant AID activity can drive off-target mutations leading to autoantibody production and B cell lymphoma. In the hyperactivated B cell responses of COVID-19, elevated AID may contribute to the autoantibody repertoire seen in Long COVID.
Can a consumer DNA test detect the rs2254987 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2254987 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for AICDA and its variants. This is not an exhaustive literature review.
- [1]PMID: 26854024
- [2]Nature Immunology
- [3]Immunity