rs2258923

What is the rs2258923 variant?

rs2258923 is a SNP (single nucleotide polymorphism) in the AICDA (Activation Induced Cytidine Deaminase) gene. It belongs to the Lymphocyte category and is part of the Lymphocyte Biology biological cluster. AICDA encodes AID, the enzyme that introduces mutations in immunoglobulin genes to enable antibody affinity maturation and isotype switching.

Biological role and pathway

This variant sits within the AICDA gene, which is involved in the somatic hypermutation and class switch recombination pathway. Genes within the Lymphocyte Biology cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: AICDA

rs2258923 is one of 2 known variants in the AICDA gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs2258923

Research into AICDA variants including rs2258923 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include AICDA and the rs2258923 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the AICDA gene

The following variants in AICDA are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions