rs1801243
Variant in the ATP7B gene (ATPase Copper Transporting Beta)
rs1801243 is a single nucleotide polymorphism (SNP) in the ATP7B gene, involved in hepatic copper export / biliary copper. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1801243 variant?
rs1801243 is a SNP (single nucleotide polymorphism) in the ATP7B (ATPase Copper Transporting Beta) gene. It belongs to the Metabolic category and is part of the Detox & Medication Sensitivity biological cluster. ATP7B encodes a hepatic copper-transporting ATPase that exports copper into bile; mutations cause Wilson's disease.
Biological role and pathway
This variant sits within the ATP7B gene, which is involved in the hepatic copper export / biliary copper pathway. Genes within the Detox & Medication Sensitivity cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1801243 and Long COVID / ME-CFS research
ATP7B-mediated copper homeostasis is critical; copper dysregulation affects antioxidant enzymes and immune function, and heterozygous variants may influence copper-dependent processes in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: ATP7B
rs1801243 is one of 2 known variants in the ATP7B gene. To understand the full biological context of this variant, explore the parent gene page.
View ATP7B gene page →Conditions studied in relation to rs1801243
Research into ATP7B variants including rs1801243 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ATP7B and the rs1801243 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the ATP7B gene
The following variants in ATP7B are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1801243 variant in the ATP7B gene?
rs1801243 is a single nucleotide polymorphism (SNP) located in the ATP7B (ATPase Copper Transporting Beta) gene, which is involved in hepatic copper export / biliary copper. ATP7B encodes a hepatic copper-transporting ATPase that exports copper into bile; mutations cause Wilson's disease.
How may the rs1801243 variant relate to Long COVID or ME/CFS?
ATP7B-mediated copper homeostasis is critical; copper dysregulation affects antioxidant enzymes and immune function, and heterozygous variants may influence copper-dependent processes in Long COVID.
Can a consumer DNA test detect the rs1801243 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1801243 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for ATP7B and its variants. This is not an exhaustive literature review.
- [1]PMID: 34088393
- [2]Nature Genetics
- [3]Hepatology