rs12944590

What is the rs12944590 variant?

rs12944590 is a SNP (single nucleotide polymorphism) in the CCK (Cholecystokinin) gene. It belongs to the Neuroendocrine category and is part of the Neurological & Cognitive Function biological cluster. CCK encodes cholecystokinin, a gut hormone that promotes bile and enzyme secretion and signals satiety via vagal afferents.

Biological role and pathway

This variant sits within the CCK gene, which is involved in the gut-brain satiety / gallbladder pathway. Genes within the Neurological & Cognitive Function cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: CCK

rs12944590 is one of 1 known variant in the CCK gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs12944590

Research into CCK variants including rs12944590 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CCK and the rs12944590 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions