rs1799864
Variant in the CCR2 gene (C-C Motif Chemokine Receptor 2)
rs1799864 is a single nucleotide polymorphism (SNP) in the CCR2 gene, involved in monocyte trafficking. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1799864 variant?
rs1799864 is a SNP (single nucleotide polymorphism) in the CCR2 (C-C Motif Chemokine Receptor 2) gene. It belongs to the Adaptive Immunity category and is part of the Adaptive Immunity biological cluster. CCR2 is the primary receptor for CCL2 and CCL7 on monocytes, facilitating their egress from bone marrow and recruitment to inflamed tissues. CCR2+ inflammatory monocytes are key drivers of tissue damage in chronic inflammatory conditions.
Biological role and pathway
This variant sits within the CCR2 gene, which is involved in the monocyte trafficking pathway. Genes within the Adaptive Immunity cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1799864 and Long COVID / ME-CFS research
CCR2+CD14+ inflammatory monocytes are elevated in Long COVID blood, contributing to vascular and tissue inflammation. CCR2 variants affecting monocyte responsiveness to CCL2 may modulate the degree of monocyte-driven tissue damage in post-COVID syndrome.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: CCR2
rs1799864 is one of 3 known variants in the CCR2 gene. To understand the full biological context of this variant, explore the parent gene page.
View CCR2 gene page →Conditions studied in relation to rs1799864
Research into CCR2 variants including rs1799864 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CCR2 and the rs1799864 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the CCR2 gene
The following variants in CCR2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1799864 variant in the CCR2 gene?
rs1799864 is a single nucleotide polymorphism (SNP) located in the CCR2 (C-C Motif Chemokine Receptor 2) gene, which is involved in monocyte trafficking. CCR2 is the primary receptor for CCL2 and CCL7 on monocytes, facilitating their egress from bone marrow and recruitment to inflamed tissues. CCR2+ inflammatory monocytes are key drivers of tissue damage in chronic inflammatory conditions.
How may the rs1799864 variant relate to Long COVID or ME/CFS?
CCR2+CD14+ inflammatory monocytes are elevated in Long COVID blood, contributing to vascular and tissue inflammation. CCR2 variants affecting monocyte responsiveness to CCL2 may modulate the degree of monocyte-driven tissue damage in post-COVID syndrome.
Can a consumer DNA test detect the rs1799864 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1799864 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for CCR2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33727702
- [2]Nature Immunology
- [3]Cell Reports