rs4806392
Variant in the CGAS gene (Cyclic GMP-AMP Synthase)
rs4806392 is a single nucleotide polymorphism (SNP) in the CGAS gene, involved in cGAS-STING cytosolic DNA sensing. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs4806392 variant?
rs4806392 is a SNP (single nucleotide polymorphism) in the CGAS (Cyclic GMP-AMP Synthase) gene. It belongs to the Antiviral category and is part of the Viral Defense & Interferon Response biological cluster. CGAS encodes cyclic GMP-AMP synthase, which detects cytosolic double-stranded DNA and synthesizes cGAMP to activate STING.
Biological role and pathway
This variant sits within the CGAS gene, which is involved in the cGAS-STING cytosolic DNA sensing pathway. Genes within the Viral Defense & Interferon Response cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs4806392 and Long COVID / ME-CFS research
cGAS-STING sensing of cytosolic mitochondrial DNA and SARS-CoV-2 components drives type I interferon responses; cGAS variants may affect the innate immune sensing of viral nucleic acids in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: CGAS
rs4806392 is one of 2 known variants in the CGAS gene. To understand the full biological context of this variant, explore the parent gene page.
View CGAS gene page →Conditions studied in relation to rs4806392
Research into CGAS variants including rs4806392 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CGAS and the rs4806392 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the CGAS gene
The following variants in CGAS are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs4806392 variant in the CGAS gene?
rs4806392 is a single nucleotide polymorphism (SNP) located in the CGAS (Cyclic GMP-AMP Synthase) gene, which is involved in cGAS-STING cytosolic DNA sensing. CGAS encodes cyclic GMP-AMP synthase, which detects cytosolic double-stranded DNA and synthesizes cGAMP to activate STING.
How may the rs4806392 variant relate to Long COVID or ME/CFS?
cGAS-STING sensing of cytosolic mitochondrial DNA and SARS-CoV-2 components drives type I interferon responses; cGAS variants may affect the innate immune sensing of viral nucleic acids in Long COVID.
Can a consumer DNA test detect the rs4806392 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs4806392 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for CGAS and its variants. This is not an exhaustive literature review.
- [1]PMID: 32217835
- [2]Science
- [3]Nature