rs2337980
Variant in the CHRNA7 gene (Cholinergic Receptor Nicotinic Alpha 7 Subunit)
rs2337980 is a single nucleotide polymorphism (SNP) in the CHRNA7 gene, involved in alpha7-nAChR / anti-inflammatory cholinergic. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2337980 variant?
rs2337980 is a SNP (single nucleotide polymorphism) in the CHRNA7 (Cholinergic Receptor Nicotinic Alpha 7 Subunit) gene. It belongs to the Neurotransmitter category and is part of the Autonomic Nervous System biological cluster. CHRNA7 encodes the alpha-7 nicotinic acetylcholine receptor, expressed on macrophages and neurons, mediating the anti-inflammatory cholinergic reflex.
Biological role and pathway
This variant sits within the CHRNA7 gene, which is involved in the alpha7-nAChR / anti-inflammatory cholinergic pathway. Genes within the Autonomic Nervous System cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2337980 and Long COVID / ME-CFS research
Alpha-7 nAChR activation suppresses macrophage TNF and cytokine release via the cholinergic anti-inflammatory pathway; variants may affect the vagus nerve-mediated anti-inflammatory reflex implicated in Long COVID dysautonomia and inflammation.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: CHRNA7
rs2337980 is one of 2 known variants in the CHRNA7 gene. To understand the full biological context of this variant, explore the parent gene page.
View CHRNA7 gene page →Conditions studied in relation to rs2337980
Research into CHRNA7 variants including rs2337980 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CHRNA7 and the rs2337980 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the CHRNA7 gene
The following variants in CHRNA7 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2337980 variant in the CHRNA7 gene?
rs2337980 is a single nucleotide polymorphism (SNP) located in the CHRNA7 (Cholinergic Receptor Nicotinic Alpha 7 Subunit) gene, which is involved in alpha7-nAChR / anti-inflammatory cholinergic. CHRNA7 encodes the alpha-7 nicotinic acetylcholine receptor, expressed on macrophages and neurons, mediating the anti-inflammatory cholinergic reflex.
How may the rs2337980 variant relate to Long COVID or ME/CFS?
Alpha-7 nAChR activation suppresses macrophage TNF and cytokine release via the cholinergic anti-inflammatory pathway; variants may affect the vagus nerve-mediated anti-inflammatory reflex implicated in Long COVID dysautonomia and inflammation.
Can a consumer DNA test detect the rs2337980 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2337980 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for CHRNA7 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33664986
- [2]Nature Genetics
- [3]Nature Reviews Immunology