rs8027814

What is the rs8027814 variant?

rs8027814 is a SNP (single nucleotide polymorphism) in the CHRNA7 (Cholinergic Receptor Nicotinic Alpha 7 Subunit) gene. It belongs to the Autonomic category and is part of the Autonomic Nervous System biological cluster. CHRNA7 encodes the alpha7 nicotinic acetylcholine receptor, which is central to the vagal anti-inflammatory reflex.

Biological role and pathway

This variant sits within the CHRNA7 gene, which is involved in the cholinergic anti-inflammatory pathway pathway. Genes within the Autonomic Nervous System cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: CHRNA7

rs8027814 is one of 2 known variants in the CHRNA7 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs8027814

Research into CHRNA7 variants including rs8027814 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CHRNA7 and the rs8027814 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the CHRNA7 gene

The following variants in CHRNA7 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions