rs110402

What is the rs110402 variant?

rs110402 is a SNP (single nucleotide polymorphism) in the CRHR1 (Corticotropin-Releasing Hormone Receptor 1) gene. It belongs to the Neuroendocrine category and is part of the Autonomic Nervous System biological cluster. CRHR1 encodes the receptor for CRH on anterior pituitary corticotrophs, mediating ACTH release and HPA axis activation.

Biological role and pathway

This variant sits within the CRHR1 gene, which is involved in the HPA axis / stress response pathway. Genes within the Autonomic Nervous System cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: CRHR1

rs110402 is one of 3 known variants in the CRHR1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs110402

Research into CRHR1 variants including rs110402 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CRHR1 and the rs110402 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the CRHR1 gene

The following variants in CRHR1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions