rs242924
Variant in the CRHR1 gene (Corticotropin-Releasing Hormone Receptor 1)
rs242924 is a single nucleotide polymorphism (SNP) in the CRHR1 gene, involved in HPA axis / stress response. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs242924 variant?
rs242924 is a SNP (single nucleotide polymorphism) in the CRHR1 (Corticotropin-Releasing Hormone Receptor 1) gene. It belongs to the Neuroendocrine category and is part of the Autonomic Nervous System biological cluster. CRHR1 encodes the receptor for CRH on anterior pituitary corticotrophs, mediating ACTH release and HPA axis activation.
Biological role and pathway
This variant sits within the CRHR1 gene, which is involved in the HPA axis / stress response pathway. Genes within the Autonomic Nervous System cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs242924 and Long COVID / ME-CFS research
CRHR1 variants affecting HPA axis sensitivity may influence stress-related symptom exacerbation and autonomic dysfunction in Long COVID and ME/CFS.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: CRHR1
rs242924 is one of 3 known variants in the CRHR1 gene. To understand the full biological context of this variant, explore the parent gene page.
View CRHR1 gene page →Conditions studied in relation to rs242924
Research into CRHR1 variants including rs242924 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CRHR1 and the rs242924 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the CRHR1 gene
The following variants in CRHR1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs242924 variant in the CRHR1 gene?
rs242924 is a single nucleotide polymorphism (SNP) located in the CRHR1 (Corticotropin-Releasing Hormone Receptor 1) gene, which is involved in HPA axis / stress response. CRHR1 encodes the receptor for CRH on anterior pituitary corticotrophs, mediating ACTH release and HPA axis activation.
How may the rs242924 variant relate to Long COVID or ME/CFS?
CRHR1 variants affecting HPA axis sensitivity may influence stress-related symptom exacerbation and autonomic dysfunction in Long COVID and ME/CFS.
Can a consumer DNA test detect the rs242924 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs242924 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for CRHR1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33664986
- [2]Nature Genetics
- [3]Molecular Psychiatry