rs3813867
Variant in the CYP2E1 gene (Cytochrome P450 Family 2 Subfamily E Member 1)
rs3813867 is a single nucleotide polymorphism (SNP) in the CYP2E1 gene, involved in Phase I xenobiotic and ethanol metabolism. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs3813867 variant?
rs3813867 is a SNP (single nucleotide polymorphism) in the CYP2E1 (Cytochrome P450 Family 2 Subfamily E Member 1) gene. It belongs to the Drug Metabolism category and is part of the Detox & Medication Sensitivity biological cluster. CYP2E1 encodes a cytochrome P450 enzyme that metabolizes ethanol, acetaminophen, and various environmental toxins.
Biological role and pathway
This variant sits within the CYP2E1 gene, which is involved in the Phase I xenobiotic and ethanol metabolism pathway. Genes within the Detox & Medication Sensitivity cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs3813867 and Long COVID / ME-CFS research
CYP2E1 activity affects generation of reactive oxygen species from toxin metabolism, which may worsen oxidative stress in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: CYP2E1
rs3813867 is one of 2 known variants in the CYP2E1 gene. To understand the full biological context of this variant, explore the parent gene page.
View CYP2E1 gene page →Conditions studied in relation to rs3813867
Research into CYP2E1 variants including rs3813867 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CYP2E1 and the rs3813867 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the CYP2E1 gene
The following variants in CYP2E1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs3813867 variant in the CYP2E1 gene?
rs3813867 is a single nucleotide polymorphism (SNP) located in the CYP2E1 (Cytochrome P450 Family 2 Subfamily E Member 1) gene, which is involved in Phase I xenobiotic and ethanol metabolism. CYP2E1 encodes a cytochrome P450 enzyme that metabolizes ethanol, acetaminophen, and various environmental toxins.
How may the rs3813867 variant relate to Long COVID or ME/CFS?
CYP2E1 activity affects generation of reactive oxygen species from toxin metabolism, which may worsen oxidative stress in Long COVID.
Can a consumer DNA test detect the rs3813867 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs3813867 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for CYP2E1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 26014458
- [2]Nature Genetics
- [3]Journal of Clinical Investigation