rs193176

What is the rs193176 variant?

rs193176 is a SNP (single nucleotide polymorphism) in the DUSP1 (Dual Specificity Phosphatase 1 (MKP-1)) gene. It belongs to the Signaling category and is part of the Immune System & Inflammation biological cluster. DUSP1 encodes MKP-1 (MAP kinase phosphatase-1), a nuclear phosphatase that inactivates p38 and JNK MAP kinases to resolve inflammatory signaling.

Biological role and pathway

This variant sits within the DUSP1 gene, which is involved in the MAPK negative regulation pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: DUSP1

rs193176 is one of 1 known variant in the DUSP1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs193176

Research into DUSP1 variants including rs193176 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include DUSP1 and the rs193176 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions