DUSP1 Gene
Dual Specificity Phosphatase 1 (MKP-1) (DUSP1) is a gene involved in MAPK negative regulation that has been studied in relation to immune function, metabolism, and chronic illness. Variants in DUSP1 may influence how the body responds to infection, inflammation, and long-term recovery.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the DUSP1 gene?
DUSP1 encodes dual specificity phosphatase 1 (mkp-1), a protein involved in MAPK negative regulation. It belongs to the Signaling category and is part of the Immune System & Inflammation biological cluster. DUSP1 encodes MKP-1 (MAP kinase phosphatase-1), a nuclear phosphatase that inactivates p38 and JNK MAP kinases to resolve inflammatory signaling.
Biological role and pathway
DUSP1 is involved in the MAPK negative regulation pathway, which plays a central role in regulating physiological processes relevant to immune defence, cellular energy, and systemic homeostasis. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function in these systems — particularly under conditions of physiological stress such as viral infection or prolonged illness.
DUSP1 and Long COVID / ME-CFS research
DUSP1 provides critical negative feedback on inflammatory MAPK signaling; variants may affect the resolution of p38/JNK-driven inflammation and contribute to chronic inflammatory state in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Known genetic variants
The following variants (SNPs) in the DUSP1 gene have been studied in relation to signaling and chronic illness. Each variant represents a single nucleotide position where individuals may carry different alleles.
- rs193176— DUSP1 variant
Conditions studied in relation to DUSP1
Research into DUSP1 variants has explored associations with the following conditions. These are areas of scientific investigation and do not imply that DUSP1 causes or treats any condition.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include DUSP1 and related genes in the immune system & inflammation pathway.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Related genes in the Immune System & Inflammation pathway
DUSP1 does not act in isolation. The following genes are functionally related and may be analysed together for a more complete picture of your genetic predispositions.
Frequently asked questions
What is the DUSP1 gene and what does it do?
DUSP1 (Dual Specificity Phosphatase 1 (MKP-1)) is involved in MAPK negative regulation. DUSP1 encodes MKP-1 (MAP kinase phosphatase-1), a nuclear phosphatase that inactivates p38 and JNK MAP kinases to resolve inflammatory signaling.
How may DUSP1 gene variants relate to Long COVID or ME/CFS?
DUSP1 provides critical negative feedback on inflammatory MAPK signaling; variants may affect the resolution of p38/JNK-driven inflammation and contribute to chronic inflammatory state in Long COVID.
Can a DNA test reveal information about my DUSP1 gene?
Consumer DNA data from 23andMe, AncestryDNA, and MyHeritage includes SNP variants for many genes. ChronicDNA analyses your raw DNA file and reports on variants that have been studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Explore your DUSP1 genetic insights
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for DUSP1. This is not an exhaustive literature review.
- [1]PMID: 32296168
- [2]Nature Genetics
- [3]Journal of Immunology