rs1051740
Variant in the EPHX1 gene (Epoxide Hydrolase 1)
rs1051740 is a single nucleotide polymorphism (SNP) in the EPHX1 gene, involved in xenobiotic metabolism. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1051740 variant?
rs1051740 is a SNP (single nucleotide polymorphism) in the EPHX1 (Epoxide Hydrolase 1) gene. It belongs to the Metabolism category and is part of the Pharmacogenomics biological cluster. EPHX1 (microsomal epoxide hydrolase) hydrolyzes reactive epoxide intermediates formed during cytochrome P450 metabolism of polycyclic aromatic hydrocarbons and other xenobiotics, providing a key detoxification function.
Biological role and pathway
This variant sits within the EPHX1 gene, which is involved in the xenobiotic metabolism pathway. Genes within the Pharmacogenomics cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1051740 and Long COVID / ME-CFS research
EPHX1 variants (His139Arg, Tyr113His) affect enzymatic activity and are associated with susceptibility to respiratory diseases. In Long COVID respiratory complications, EPHX1-mediated detoxification of reactive metabolites may influence lung recovery.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: EPHX1
rs1051740 is one of 3 known variants in the EPHX1 gene. To understand the full biological context of this variant, explore the parent gene page.
View EPHX1 gene page →Conditions studied in relation to rs1051740
Research into EPHX1 variants including rs1051740 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include EPHX1 and the rs1051740 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the EPHX1 gene
The following variants in EPHX1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1051740 variant in the EPHX1 gene?
rs1051740 is a single nucleotide polymorphism (SNP) located in the EPHX1 (Epoxide Hydrolase 1) gene, which is involved in xenobiotic metabolism. EPHX1 (microsomal epoxide hydrolase) hydrolyzes reactive epoxide intermediates formed during cytochrome P450 metabolism of polycyclic aromatic hydrocarbons and other xenobiotics, providing a key detoxification function.
How may the rs1051740 variant relate to Long COVID or ME/CFS?
EPHX1 variants (His139Arg, Tyr113His) affect enzymatic activity and are associated with susceptibility to respiratory diseases. In Long COVID respiratory complications, EPHX1-mediated detoxification of reactive metabolites may influence lung recovery.
Can a consumer DNA test detect the rs1051740 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1051740 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for EPHX1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 26872069
- [2]Pharmacogenetics and Genomics
- [3]Environmental Health Perspectives