rs13181
Variant in the ERCC2 gene (ERCC Excision Repair 2 (XPD))
rs13181 is a single nucleotide polymorphism (SNP) in the ERCC2 gene, involved in nucleotide excision repair. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs13181 variant?
rs13181 is a SNP (single nucleotide polymorphism) in the ERCC2 (ERCC Excision Repair 2 (XPD)) gene. It belongs to the Dna Repair category and is part of the DNA Repair biological cluster. ERCC2 encodes XPD helicase, a TFIIH subunit that unwinds DNA during nucleotide excision repair.
Biological role and pathway
This variant sits within the ERCC2 gene, which is involved in the nucleotide excision repair pathway. Genes within the DNA Repair cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs13181 and Long COVID / ME-CFS research
ERCC2 variants affecting DNA repair efficiency may allow accumulation of oxidative DNA lesions contributing to cellular dysfunction in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: ERCC2
rs13181 is one of 2 known variants in the ERCC2 gene. To understand the full biological context of this variant, explore the parent gene page.
View ERCC2 gene page →Conditions studied in relation to rs13181
Research into ERCC2 variants including rs13181 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ERCC2 and the rs13181 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the ERCC2 gene
The following variants in ERCC2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs13181 variant in the ERCC2 gene?
rs13181 is a single nucleotide polymorphism (SNP) located in the ERCC2 (ERCC Excision Repair 2 (XPD)) gene, which is involved in nucleotide excision repair. ERCC2 encodes XPD helicase, a TFIIH subunit that unwinds DNA during nucleotide excision repair.
How may the rs13181 variant relate to Long COVID or ME/CFS?
ERCC2 variants affecting DNA repair efficiency may allow accumulation of oxidative DNA lesions contributing to cellular dysfunction in Long COVID.
Can a consumer DNA test detect the rs13181 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs13181 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for ERCC2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 26014458
- [2]Nature Genetics
- [3]Journal of Clinical Investigation