rs2427837
Variant in the FCER1A gene (Fc Epsilon Receptor Ia)
rs2427837 is a single nucleotide polymorphism (SNP) in the FCER1A gene, involved in IgE receptor / mast cell and basophil activation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2427837 variant?
rs2427837 is a SNP (single nucleotide polymorphism) in the FCER1A (Fc Epsilon Receptor Ia) gene. It belongs to the Immune Signaling category and is part of the Histamine & MCAS biological cluster. FCER1A encodes the alpha subunit of the high-affinity IgE receptor, which binds IgE on mast cells and basophils to initiate allergic responses.
Biological role and pathway
This variant sits within the FCER1A gene, which is involved in the IgE receptor / mast cell and basophil activation pathway. Genes within the Histamine & MCAS cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2427837 and Long COVID / ME-CFS research
FcεRIα variants affect IgE receptor expression and mast cell sensitivity; elevated IgE responses and mast cell hyperactivation in Long COVID may be influenced by FCER1A variants.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: FCER1A
rs2427837 is one of 2 known variants in the FCER1A gene. To understand the full biological context of this variant, explore the parent gene page.
View FCER1A gene page →Conditions studied in relation to rs2427837
Research into FCER1A variants including rs2427837 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include FCER1A and the rs2427837 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the FCER1A gene
The following variants in FCER1A are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2427837 variant in the FCER1A gene?
rs2427837 is a single nucleotide polymorphism (SNP) located in the FCER1A (Fc Epsilon Receptor Ia) gene, which is involved in IgE receptor / mast cell and basophil activation. FCER1A encodes the alpha subunit of the high-affinity IgE receptor, which binds IgE on mast cells and basophils to initiate allergic responses.
How may the rs2427837 variant relate to Long COVID or ME/CFS?
FcεRIα variants affect IgE receptor expression and mast cell sensitivity; elevated IgE responses and mast cell hyperactivation in Long COVID may be influenced by FCER1A variants.
Can a consumer DNA test detect the rs2427837 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2427837 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for FCER1A and its variants. This is not an exhaustive literature review.
- [1]PMID: 33398161
- [2]Nature Genetics
- [3]Journal of Allergy and Clinical Immunology