rs4146315

What is the rs4146315 variant?

rs4146315 is a SNP (single nucleotide polymorphism) in the FCER1A (Fc Epsilon Receptor Ia) gene. It belongs to the Mast Cell category and is part of the Mast Cell & Allergy biological cluster. FCER1A encodes the alpha chain of the high-affinity IgE receptor on mast cells and basophils, triggering allergic responses upon IgE binding.

Biological role and pathway

This variant sits within the FCER1A gene, which is involved in the IgE-mediated mast cell activation pathway. Genes within the Mast Cell & Allergy cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: FCER1A

rs4146315 is one of 2 known variants in the FCER1A gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs4146315

Research into FCER1A variants including rs4146315 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include FCER1A and the rs4146315 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the FCER1A gene

The following variants in FCER1A are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions