rs1268170
Variant in the FOXO3 gene (Forkhead Box O3)
rs1268170 is a single nucleotide polymorphism (SNP) in the FOXO3 gene, involved in oxidative stress response / longevity / apoptosis. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1268170 variant?
rs1268170 is a SNP (single nucleotide polymorphism) in the FOXO3 (Forkhead Box O3) gene. It belongs to the Signaling category and is part of the Oxidative Stress biological cluster. FOXO3 encodes a forkhead transcription factor activated by oxidative stress and AMPK that drives expression of antioxidant genes and autophagy.
Biological role and pathway
This variant sits within the FOXO3 gene, which is involved in the oxidative stress response / longevity / apoptosis pathway. Genes within the Oxidative Stress cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1268170 and Long COVID / ME-CFS research
FOXO3 variants are among the strongest longevity-associated genetic variants; they affect oxidative stress resilience and immune cell homeostasis, potentially relevant to Long COVID recovery.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: FOXO3
rs1268170 is one of 3 known variants in the FOXO3 gene. To understand the full biological context of this variant, explore the parent gene page.
View FOXO3 gene page →Conditions studied in relation to rs1268170
Research into FOXO3 variants including rs1268170 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include FOXO3 and the rs1268170 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the FOXO3 gene
The following variants in FOXO3 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1268170 variant in the FOXO3 gene?
rs1268170 is a single nucleotide polymorphism (SNP) located in the FOXO3 (Forkhead Box O3) gene, which is involved in oxidative stress response / longevity / apoptosis. FOXO3 encodes a forkhead transcription factor activated by oxidative stress and AMPK that drives expression of antioxidant genes and autophagy.
How may the rs1268170 variant relate to Long COVID or ME/CFS?
FOXO3 variants are among the strongest longevity-associated genetic variants; they affect oxidative stress resilience and immune cell homeostasis, potentially relevant to Long COVID recovery.
Can a consumer DNA test detect the rs1268170 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1268170 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for FOXO3 and its variants. This is not an exhaustive literature review.
- [1]PMID: 34088393
- [2]Nature Genetics
- [3]PNAS