rs2232365
Variant in the FOXP3 gene (Forkhead Box P3)
rs2232365 is a single nucleotide polymorphism (SNP) in the FOXP3 gene, involved in regulatory T cell development. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2232365 variant?
rs2232365 is a SNP (single nucleotide polymorphism) in the FOXP3 (Forkhead Box P3) gene. It belongs to the Immune Regulation category and is part of the Immune Regulation biological cluster. FOXP3 encodes the master transcription factor for regulatory T cells (Tregs), which suppress excessive immune activation.
Biological role and pathway
This variant sits within the FOXP3 gene, which is involved in the regulatory T cell development pathway. Genes within the Immune Regulation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2232365 and Long COVID / ME-CFS research
FOXP3 variants affecting Treg function may impair immune regulation and contribute to autoimmune features and persistent inflammation in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: FOXP3
rs2232365 is one of 2 known variants in the FOXP3 gene. To understand the full biological context of this variant, explore the parent gene page.
View FOXP3 gene page →Conditions studied in relation to rs2232365
Research into FOXP3 variants including rs2232365 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include FOXP3 and the rs2232365 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the FOXP3 gene
The following variants in FOXP3 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2232365 variant in the FOXP3 gene?
rs2232365 is a single nucleotide polymorphism (SNP) located in the FOXP3 (Forkhead Box P3) gene, which is involved in regulatory T cell development. FOXP3 encodes the master transcription factor for regulatory T cells (Tregs), which suppress excessive immune activation.
How may the rs2232365 variant relate to Long COVID or ME/CFS?
FOXP3 variants affecting Treg function may impair immune regulation and contribute to autoimmune features and persistent inflammation in Long COVID.
Can a consumer DNA test detect the rs2232365 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2232365 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for FOXP3 and its variants. This is not an exhaustive literature review.
- [1]PMID: 29925876
- [2]Nature Genetics
- [3]Journal of Clinical Investigation