rs5902434
Variant in the FOXP3 gene (Forkhead Box P3)
rs5902434 is a single nucleotide polymorphism (SNP) in the FOXP3 gene, involved in Treg differentiation / immune tolerance. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs5902434 variant?
rs5902434 is a SNP (single nucleotide polymorphism) in the FOXP3 (Forkhead Box P3) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. FOXP3 encodes the master transcription factor for regulatory T cells (Tregs), essential for immune tolerance.
Biological role and pathway
This variant sits within the FOXP3 gene, which is involved in the Treg differentiation / immune tolerance pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs5902434 and Long COVID / ME-CFS research
FOXP3+ Tregs are required for immune homeostasis; reduced Treg function documented in Long COVID may contribute to persistent immune activation and autoimmunity.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: FOXP3
rs5902434 is one of 2 known variants in the FOXP3 gene. To understand the full biological context of this variant, explore the parent gene page.
View FOXP3 gene page →Conditions studied in relation to rs5902434
Research into FOXP3 variants including rs5902434 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include FOXP3 and the rs5902434 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the FOXP3 gene
The following variants in FOXP3 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs5902434 variant in the FOXP3 gene?
rs5902434 is a single nucleotide polymorphism (SNP) located in the FOXP3 (Forkhead Box P3) gene, which is involved in Treg differentiation / immune tolerance. FOXP3 encodes the master transcription factor for regulatory T cells (Tregs), essential for immune tolerance.
How may the rs5902434 variant relate to Long COVID or ME/CFS?
FOXP3+ Tregs are required for immune homeostasis; reduced Treg function documented in Long COVID may contribute to persistent immune activation and autoimmunity.
Can a consumer DNA test detect the rs5902434 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs5902434 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for FOXP3 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32296168
- [2]Nature Immunology
- [3]NEJM