rs1047781
Variant in the FUT2 gene (Fucosyltransferase 2)
rs1047781 is a single nucleotide polymorphism (SNP) in the FUT2 gene, involved in gut mucosal immunity. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1047781 variant?
rs1047781 is a SNP (single nucleotide polymorphism) in the FUT2 (Fucosyltransferase 2) gene. It belongs to the Gut Microbiome category and is part of the Gut & Microbiome Interaction biological cluster. FUT2 encodes fucosyltransferase 2, which determines ABO blood group secretor status and influences gut microbiome composition.
Biological role and pathway
This variant sits within the FUT2 gene, which is involved in the gut mucosal immunity pathway. Genes within the Gut & Microbiome Interaction cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1047781 and Long COVID / ME-CFS research
FUT2 non-secretor status affects gut microbiome diversity and mucosal immunity, potentially influencing gut-related Long COVID symptoms.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: FUT2
rs1047781 is one of 2 known variants in the FUT2 gene. To understand the full biological context of this variant, explore the parent gene page.
View FUT2 gene page →Conditions studied in relation to rs1047781
Research into FUT2 variants including rs1047781 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include FUT2 and the rs1047781 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the FUT2 gene
The following variants in FUT2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1047781 variant in the FUT2 gene?
rs1047781 is a single nucleotide polymorphism (SNP) located in the FUT2 (Fucosyltransferase 2) gene, which is involved in gut mucosal immunity. FUT2 encodes fucosyltransferase 2, which determines ABO blood group secretor status and influences gut microbiome composition.
How may the rs1047781 variant relate to Long COVID or ME/CFS?
FUT2 non-secretor status affects gut microbiome diversity and mucosal immunity, potentially influencing gut-related Long COVID symptoms.
Can a consumer DNA test detect the rs1047781 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1047781 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for FUT2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 29925876
- [2]Nature Genetics
- [3]Journal of Clinical Investigation