rs1050828
Variant in the G6PD gene (Glucose-6-Phosphate Dehydrogenase)
rs1050828 is a single nucleotide polymorphism (SNP) in the G6PD gene, involved in pentose phosphate pathway / NADPH generation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1050828 variant?
rs1050828 is a SNP (single nucleotide polymorphism) in the G6PD (Glucose-6-Phosphate Dehydrogenase) gene. It belongs to the Oxidative Stress category and is part of the Oxidative Stress biological cluster. G6PD encodes glucose-6-phosphate dehydrogenase, the critical enzyme for generating NADPH via the pentose phosphate pathway in red blood cells.
Biological role and pathway
This variant sits within the G6PD gene, which is involved in the pentose phosphate pathway / NADPH generation pathway. Genes within the Oxidative Stress cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1050828 and Long COVID / ME-CFS research
G6PD deficiency increases red cell susceptibility to oxidative hemolysis; G6PD variants are associated with COVID-19 severity in some populations and may affect Long COVID through increased oxidative stress.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: G6PD
rs1050828 is one of 2 known variants in the G6PD gene. To understand the full biological context of this variant, explore the parent gene page.
View G6PD gene page →Conditions studied in relation to rs1050828
Research into G6PD variants including rs1050828 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include G6PD and the rs1050828 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the G6PD gene
The following variants in G6PD are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1050828 variant in the G6PD gene?
rs1050828 is a single nucleotide polymorphism (SNP) located in the G6PD (Glucose-6-Phosphate Dehydrogenase) gene, which is involved in pentose phosphate pathway / NADPH generation. G6PD encodes glucose-6-phosphate dehydrogenase, the critical enzyme for generating NADPH via the pentose phosphate pathway in red blood cells.
How may the rs1050828 variant relate to Long COVID or ME/CFS?
G6PD deficiency increases red cell susceptibility to oxidative hemolysis; G6PD variants are associated with COVID-19 severity in some populations and may affect Long COVID through increased oxidative stress.
Can a consumer DNA test detect the rs1050828 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1050828 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for G6PD and its variants. This is not an exhaustive literature review.
- [1]PMID: 34088393
- [2]Nature Genetics
- [3]Blood