rs4670417
Variant in the GP1BA gene (Glycoprotein Ib Platelet Subunit Alpha)
rs4670417 is a single nucleotide polymorphism (SNP) in the GP1BA gene, involved in platelet adhesion. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs4670417 variant?
rs4670417 is a SNP (single nucleotide polymorphism) in the GP1BA (Glycoprotein Ib Platelet Subunit Alpha) gene. It belongs to the Coagulation category and is part of the Coagulation & Vascular biological cluster. GPIbα (GP1BA) is the major VWF-binding subunit of the GPIb-IX-V complex, mediating platelet tethering to damaged vascular subendothelium under high shear stress. It also binds thrombin and P-selectin.
Biological role and pathway
This variant sits within the GP1BA gene, which is involved in the platelet adhesion pathway. Genes within the Coagulation & Vascular cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs4670417 and Long COVID / ME-CFS research
GPIbα-VWF interactions initiate platelet adhesion at sites of endothelial damage. In Long COVID, elevated VWF and platelet hyperactivation may drive GP1BA-dependent platelet-endothelium interactions contributing to microthrombi and vascular occlusion.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: GP1BA
rs4670417 is one of 3 known variants in the GP1BA gene. To understand the full biological context of this variant, explore the parent gene page.
View GP1BA gene page →Conditions studied in relation to rs4670417
Research into GP1BA variants including rs4670417 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include GP1BA and the rs4670417 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the GP1BA gene
The following variants in GP1BA are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs4670417 variant in the GP1BA gene?
rs4670417 is a single nucleotide polymorphism (SNP) located in the GP1BA (Glycoprotein Ib Platelet Subunit Alpha) gene, which is involved in platelet adhesion. GPIbα (GP1BA) is the major VWF-binding subunit of the GPIb-IX-V complex, mediating platelet tethering to damaged vascular subendothelium under high shear stress. It also binds thrombin and P-selectin.
How may the rs4670417 variant relate to Long COVID or ME/CFS?
GPIbα-VWF interactions initiate platelet adhesion at sites of endothelial damage. In Long COVID, elevated VWF and platelet hyperactivation may drive GP1BA-dependent platelet-endothelium interactions contributing to microthrombi and vascular occlusion.
Can a consumer DNA test detect the rs4670417 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs4670417 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for GP1BA and its variants. This is not an exhaustive literature review.
- [1]PMID: 31860018
- [2]Blood
- [3]Journal of Thrombosis and Haemostasis