rs4748400
Variant in the GP1BA gene (Glycoprotein Ib Platelet Subunit Alpha)
rs4748400 is a single nucleotide polymorphism (SNP) in the GP1BA gene, involved in platelet VWF receptor / primary hemostasis. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs4748400 variant?
rs4748400 is a SNP (single nucleotide polymorphism) in the GP1BA (Glycoprotein Ib Platelet Subunit Alpha) gene. It belongs to the Coagulation category and is part of the Coagulation & Microcirculation biological cluster. GP1BA encodes GPIbα, the VWF-binding subunit of the GPIb-V-IX complex, mediating platelet tethering and activation at high shear.
Biological role and pathway
This variant sits within the GP1BA gene, which is involved in the platelet VWF receptor / primary hemostasis pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs4748400 and Long COVID / ME-CFS research
GPIbα mediates platelet adhesion to VWF at sites of vascular injury; variants (Thr145Met, VNTR) affect platelet-VWF interaction, potentially influencing microthrombus formation in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: GP1BA
rs4748400 is one of 3 known variants in the GP1BA gene. To understand the full biological context of this variant, explore the parent gene page.
View GP1BA gene page →Conditions studied in relation to rs4748400
Research into GP1BA variants including rs4748400 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include GP1BA and the rs4748400 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the GP1BA gene
The following variants in GP1BA are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs4748400 variant in the GP1BA gene?
rs4748400 is a single nucleotide polymorphism (SNP) located in the GP1BA (Glycoprotein Ib Platelet Subunit Alpha) gene, which is involved in platelet VWF receptor / primary hemostasis. GP1BA encodes GPIbα, the VWF-binding subunit of the GPIb-V-IX complex, mediating platelet tethering and activation at high shear.
How may the rs4748400 variant relate to Long COVID or ME/CFS?
GPIbα mediates platelet adhesion to VWF at sites of vascular injury; variants (Thr145Met, VNTR) affect platelet-VWF interaction, potentially influencing microthrombus formation in Long COVID.
Can a consumer DNA test detect the rs4748400 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs4748400 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for GP1BA and its variants. This is not an exhaustive literature review.
- [1]PMID: 32966261
- [2]Nature Genetics
- [3]Blood