rs1613662
Variant in the GP6 gene (Glycoprotein VI Platelet)
rs1613662 is a single nucleotide polymorphism (SNP) in the GP6 gene, involved in platelet collagen signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1613662 variant?
rs1613662 is a SNP (single nucleotide polymorphism) in the GP6 (Glycoprotein VI Platelet) gene. It belongs to the Coagulation category and is part of the Coagulation & Vascular biological cluster. GPVI is the primary platelet receptor for collagen, mediating platelet activation upon contact with exposed subendothelial collagen. It signals through the FcRγ ITAM and is a major activating receptor for arterial thrombosis.
Biological role and pathway
This variant sits within the GP6 gene, which is involved in the platelet collagen signaling pathway. Genes within the Coagulation & Vascular cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1613662 and Long COVID / ME-CFS research
GPVI-collagen interactions may be triggered by endothelial damage and exposed extracellular matrix in COVID-19. Platelet GPVI shedding generates soluble GPVI as a marker of platelet activation; GP6 variants affecting collagen-induced platelet activation may influence microthrombi formation in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: GP6
rs1613662 is one of 3 known variants in the GP6 gene. To understand the full biological context of this variant, explore the parent gene page.
View GP6 gene page →Conditions studied in relation to rs1613662
Research into GP6 variants including rs1613662 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include GP6 and the rs1613662 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the GP6 gene
The following variants in GP6 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1613662 variant in the GP6 gene?
rs1613662 is a single nucleotide polymorphism (SNP) located in the GP6 (Glycoprotein VI Platelet) gene, which is involved in platelet collagen signaling. GPVI is the primary platelet receptor for collagen, mediating platelet activation upon contact with exposed subendothelial collagen. It signals through the FcRγ ITAM and is a major activating receptor for arterial thrombosis.
How may the rs1613662 variant relate to Long COVID or ME/CFS?
GPVI-collagen interactions may be triggered by endothelial damage and exposed extracellular matrix in COVID-19. Platelet GPVI shedding generates soluble GPVI as a marker of platelet activation; GP6 variants affecting collagen-induced platelet activation may influence microthrombi formation in Long COVID.
Can a consumer DNA test detect the rs1613662 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1613662 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for GP6 and its variants. This is not an exhaustive literature review.
- [1]PMID: 29476082
- [2]Arteriosclerosis Thrombosis and Vascular Biology
- [3]Blood