rs9810453

What is the rs9810453 variant?

rs9810453 is a SNP (single nucleotide polymorphism) in the GP6 (Glycoprotein VI Platelet) gene. It belongs to the Coagulation category and is part of the Coagulation & Microcirculation biological cluster. GP6 encodes glycoprotein VI, the primary platelet receptor for collagen that mediates platelet activation at sites of vessel injury.

Biological role and pathway

This variant sits within the GP6 gene, which is involved in the platelet collagen receptor / activation pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: GP6

rs9810453 is one of 3 known variants in the GP6 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs9810453

Research into GP6 variants including rs9810453 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include GP6 and the rs9810453 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the GP6 gene

The following variants in GP6 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions