rs8177412

What is the rs8177412 variant?

rs8177412 is a SNP (single nucleotide polymorphism) in the GPX3 (Glutathione Peroxidase 3) gene. It belongs to the Oxidative Stress category and is part of the Oxidative Stress biological cluster. GPX3 encodes the plasma/extracellular glutathione peroxidase that protects circulating cells and vascular endothelium from oxidative damage.

Biological role and pathway

This variant sits within the GPX3 gene, which is involved in the plasma antioxidant defense pathway. Genes within the Oxidative Stress cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: GPX3

rs8177412 is one of 1 known variant in the GPX3 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs8177412

Research into GPX3 variants including rs8177412 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include GPX3 and the rs8177412 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions