rs366631

What is the rs366631 variant?

rs366631 is a SNP (single nucleotide polymorphism) in the GSTM1 (Glutathione S-Transferase Mu 1) gene. It belongs to the Oxidative Stress category and is part of the Oxidative Stress biological cluster. GSTM1 encodes a glutathione transferase involved in the conjugation of glutathione with electrophilic and toxic compounds.

Biological role and pathway

This variant sits within the GSTM1 gene, which is involved in the Phase II detoxification pathway. Genes within the Oxidative Stress cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: GSTM1

rs366631 is one of 2 known variants in the GSTM1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs366631

Research into GSTM1 variants including rs366631 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include GSTM1 and the rs366631 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the GSTM1 gene

The following variants in GSTM1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions