rs1138272
Variant in the GSTP1 gene (Glutathione S-Transferase Pi 1)
rs1138272 is a single nucleotide polymorphism (SNP) in the GSTP1 gene, involved in glutathione conjugation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1138272 variant?
rs1138272 is a SNP (single nucleotide polymorphism) in the GSTP1 (Glutathione S-Transferase Pi 1) gene. It belongs to the Metabolism category and is part of the Pharmacogenomics biological cluster. GSTP1 is a glutathione transferase highly expressed in lung and brain that detoxifies reactive oxygen species, electrophiles, and chemotherapy agents. The Ile105Val (rs1695) variant affects substrate specificity.
Biological role and pathway
This variant sits within the GSTP1 gene, which is involved in the glutathione conjugation pathway. Genes within the Pharmacogenomics cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1138272 and Long COVID / ME-CFS research
GSTP1 is highly expressed in respiratory epithelium and is relevant to lung antioxidant defense. GSTP1 Ile105Val affects oxidative stress susceptibility in lung tissue, potentially influencing the degree of oxidative damage during COVID-19 pneumonia.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: GSTP1
rs1138272 is one of 3 known variants in the GSTP1 gene. To understand the full biological context of this variant, explore the parent gene page.
View GSTP1 gene page →Conditions studied in relation to rs1138272
Research into GSTP1 variants including rs1138272 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include GSTP1 and the rs1138272 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the GSTP1 gene
The following variants in GSTP1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1138272 variant in the GSTP1 gene?
rs1138272 is a single nucleotide polymorphism (SNP) located in the GSTP1 (Glutathione S-Transferase Pi 1) gene, which is involved in glutathione conjugation. GSTP1 is a glutathione transferase highly expressed in lung and brain that detoxifies reactive oxygen species, electrophiles, and chemotherapy agents. The Ile105Val (rs1695) variant affects substrate specificity.
How may the rs1138272 variant relate to Long COVID or ME/CFS?
GSTP1 is highly expressed in respiratory epithelium and is relevant to lung antioxidant defense. GSTP1 Ile105Val affects oxidative stress susceptibility in lung tissue, potentially influencing the degree of oxidative damage during COVID-19 pneumonia.
Can a consumer DNA test detect the rs1138272 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1138272 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for GSTP1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 28673407
- [2]Lung Cancer
- [3]Free Radical Biology and Medicine