rs2266637
Variant in the GSTT1 gene (Glutathione S-Transferase Theta 1)
rs2266637 is a single nucleotide polymorphism (SNP) in the GSTT1 gene, involved in Phase II detoxification. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2266637 variant?
rs2266637 is a SNP (single nucleotide polymorphism) in the GSTT1 (Glutathione S-Transferase Theta 1) gene. It belongs to the Oxidative Stress category and is part of the Oxidative Stress biological cluster. GSTT1 encodes a glutathione transferase that metabolizes small organic electrophiles and certain halogenated compounds.
Biological role and pathway
This variant sits within the GSTT1 gene, which is involved in the Phase II detoxification pathway. Genes within the Oxidative Stress cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2266637 and Long COVID / ME-CFS research
GSTT1 null polymorphism impairs detoxification of reactive compounds and may contribute to oxidative burden in Long COVID patients.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: GSTT1
rs2266637 is one of 2 known variants in the GSTT1 gene. To understand the full biological context of this variant, explore the parent gene page.
View GSTT1 gene page →Conditions studied in relation to rs2266637
Research into GSTT1 variants including rs2266637 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include GSTT1 and the rs2266637 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the GSTT1 gene
The following variants in GSTT1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2266637 variant in the GSTT1 gene?
rs2266637 is a single nucleotide polymorphism (SNP) located in the GSTT1 (Glutathione S-Transferase Theta 1) gene, which is involved in Phase II detoxification. GSTT1 encodes a glutathione transferase that metabolizes small organic electrophiles and certain halogenated compounds.
How may the rs2266637 variant relate to Long COVID or ME/CFS?
GSTT1 null polymorphism impairs detoxification of reactive compounds and may contribute to oxidative burden in Long COVID patients.
Can a consumer DNA test detect the rs2266637 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2266637 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for GSTT1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 26014458
- [2]Nature Genetics
- [3]Journal of Clinical Investigation