rs1036199

What is the rs1036199 variant?

rs1036199 is a SNP (single nucleotide polymorphism) in the HAVCR2 (Hepatitis A Virus Cellular Receptor 2 (TIM-3)) gene. It belongs to the Immune Checkpoint category and is part of the Immune Checkpoints biological cluster. HAVCR2 encodes TIM-3, an inhibitory receptor expressed on exhausted T cells, regulatory T cells, and innate immune cells.

Biological role and pathway

This variant sits within the HAVCR2 gene, which is involved in the T cell and innate immune regulation pathway. Genes within the Immune Checkpoints cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: HAVCR2

rs1036199 is one of 2 known variants in the HAVCR2 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs1036199

Research into HAVCR2 variants including rs1036199 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include HAVCR2 and the rs1036199 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the HAVCR2 gene

The following variants in HAVCR2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions