rs10515746

What is the rs10515746 variant?

rs10515746 is a SNP (single nucleotide polymorphism) in the HAVCR2 (Hepatitis A Virus Cellular Receptor 2 (TIM-3)) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. HAVCR2 encodes TIM-3, an immune checkpoint receptor on exhausted T cells and innate immune cells that promotes T cell dysfunction.

Biological role and pathway

This variant sits within the HAVCR2 gene, which is involved in the T cell exhaustion / innate immune regulation pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: HAVCR2

rs10515746 is one of 2 known variants in the HAVCR2 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs10515746

Research into HAVCR2 variants including rs10515746 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include HAVCR2 and the rs10515746 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the HAVCR2 gene

The following variants in HAVCR2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions