rs1741981

What is the rs1741981 variant?

rs1741981 is a SNP (single nucleotide polymorphism) in the HDAC1 (Histone Deacetylase 1) gene. It belongs to the Epigenetics category and is part of the Epigenetics & Gene Regulation biological cluster. HDAC1 encodes a class I histone deacetylase that removes acetyl groups from histones, compacting chromatin and repressing transcription.

Biological role and pathway

This variant sits within the HDAC1 gene, which is involved in the histone deacetylation pathway. Genes within the Epigenetics & Gene Regulation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: HDAC1

rs1741981 is one of 1 known variant in the HDAC1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs1741981

Research into HDAC1 variants including rs1741981 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include HDAC1 and the rs1741981 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the HDAC1 gene

The following variants in HDAC1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions