rs8079025
Variant in the HDAC1 gene (Histone Deacetylase 1)
rs8079025 is a single nucleotide polymorphism (SNP) in the HDAC1 gene, involved in chromatin remodeling / gene silencing. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs8079025 variant?
rs8079025 is a SNP (single nucleotide polymorphism) in the HDAC1 (Histone Deacetylase 1) gene. It belongs to the Epigenetics category and is part of the Methylation & Neurotransmitters biological cluster. HDAC1 encodes histone deacetylase 1, which removes acetyl groups from histone lysines to compact chromatin and silence gene expression.
Biological role and pathway
This variant sits within the HDAC1 gene, which is involved in the chromatin remodeling / gene silencing pathway. Genes within the Methylation & Neurotransmitters cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs8079025 and Long COVID / ME-CFS research
HDAC-mediated chromatin remodeling is implicated in immune cell epigenetic changes during viral infection; HDAC1 variants may affect epigenetic reprogramming in COVID-19 and contribute to Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: HDAC1
rs8079025 is one of 1 known variant in the HDAC1 gene. To understand the full biological context of this variant, explore the parent gene page.
View HDAC1 gene page →Conditions studied in relation to rs8079025
Research into HDAC1 variants including rs8079025 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include HDAC1 and the rs8079025 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the HDAC1 gene
The following variants in HDAC1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs8079025 variant in the HDAC1 gene?
rs8079025 is a single nucleotide polymorphism (SNP) located in the HDAC1 (Histone Deacetylase 1) gene, which is involved in chromatin remodeling / gene silencing. HDAC1 encodes histone deacetylase 1, which removes acetyl groups from histone lysines to compact chromatin and silence gene expression.
How may the rs8079025 variant relate to Long COVID or ME/CFS?
HDAC-mediated chromatin remodeling is implicated in immune cell epigenetic changes during viral infection; HDAC1 variants may affect epigenetic reprogramming in COVID-19 and contribute to Long COVID.
Can a consumer DNA test detect the rs8079025 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs8079025 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for HDAC1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33664986
- [2]Nature Genetics
- [3]Cell